New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. doi: 10.1016/j.bmcl.2004.03.067.

Authors

Ingrid Devillers¹, Isabelle Pevet, Henry Jacobelli, Corinne Durand, Véronique Fasquelle, Jocelyne Puaud, Bernard Gaudillière, Moulay Idrissi, François Moreau, Roger Wrigglesworth

Affiliation

¹ Pfizer Global Research and Development, Fresnes Laboratories, 3-9 Rue de la Loge, F-94265 Fresnes Cedex, France. ingriddevillers@hotmail.com

PMID: 15149695
DOI: 10.1016/j.bmcl.2004.03.067

No abstract available

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
3',5'-Cyclic-AMP Phosphodiesterases / metabolism
Azulenes
Cyclic Nucleotide Phosphodiesterases, Type 4
Cycloheptanes / chemistry*
Cycloheptanes / pharmacology
Phosphodiesterase Inhibitors / chemistry*
Phosphodiesterase Inhibitors / pharmacology

Substances

Azulenes
Cycloheptanes
Phosphodiesterase Inhibitors
azulene
3',5'-Cyclic-AMP Phosphodiesterases
Cyclic Nucleotide Phosphodiesterases, Type 4